A recent study indicates that patients who come off new slimming jabs like semaglutide or tirzepatide can put back on lost weight much more quickly than those who stop traditional lifestyle programs.
Research printed in a leading health publication points out that while overweight people can lose substantial amounts of their body weight while undergoing treatment, the weight returns at an average rate of nearly a kilo each month upon discontinuation.
"Individuals purchasing these treatments should be informed of the danger of fast weight regain when the treatment ends," warns researcher Dr. Susan Jebb.
That rate of regain means a return to pre-treatment mass in about one and a half years.
Comparing Approaches
The study, which reviewed 37 of studies involving over 9,000 of participants, compared the results of GLP-1 agonists with conventional dieting.
The team note that individuals who shed pounds through lifestyle changes alone typically see a more gradual weight regain—around 0.1 kg a month—once they finish.
Understanding the Rapid Rebound
Experts propose the mode of action of the injections is key to understanding the amplified weight return.
These medications mimic a natural hormone called GLP-1, which moderates feelings of fullness.
"Sustained high doses of the hormone levels far above than normal could lead to the body to generate a reduced amount of its own natural hormone, and may also reduce sensitivity to its effects," said Dr. Adam Collins, a dietetics expert.
"Stopping of this medication results in appetite is uncontrolled, making excessive eating a significant risk."
A Chronic Disease?
Health authorities recommend the jabs for people with obesity-related medical conditions, accompanied by recommended lifestyle changes.
Many experts argue that, given the high risk of weight regain, the therapy is often life-long.
This view is reinforced by drug manufacturers, who note that the findings "underscore the persistent nature of excess weight," comparing it to managing diseases like high blood pressure.
User Experiences
Individuals who have come off the jabs describe a sudden resurgence of cravings.
"I experienced something flipping and you become starving," described a patient.
This challenge is compounded if patients have not developed permanent lifestyle or habit changes during treatment.
Growing Use
Survey data indicate that millions of people in the UK have used these injections in the past year, with demand remaining high.
- Adoption is more common among females compared to men.
- The 40s and 50s age group shows the greatest usage rates.
- Many obtain the drugs through private healthcare rather than public health services.
In conclusion, researchers caution that while the jabs are powerful agents for shedding pounds, they are not a permanent cure and lasting health benefits hinges on integrated lifestyle management.